Modern Approaches to the Treatment of Lichen Planus
https://doi.org/10.36107/hfb.2019.i2.s162
Abstract
Lichen planus (LP) is a chronic relapsing inflammatory skin disease. Despite the fact that a large number of drugs are prescribed for the treatment of LP, some of them lack a clear evidence base, and some of the drugs may not be used in all patients due to problems with the safety profile. The purpose of this study is to analyze approaches to the treatment of patients with LP to help doctors choose the best way to treat such patients. A review of articles on the treatment of LP was carried out using electronic databases of Scopus, Web of Science, Medline, PubMed and elibrary.ru. Topical corticosteroids and calcineurin inhibitors are modern first-line drugs. Unfortunately, there are no large randomized controlled trials to confirm the efficacy, safety, and tolerability of other treatment methods for LP, and many recommendations are based on trials with small sample sizes; they lack of standardized outcome indicators with controlled duration of treatment. It should be noted that in all cases the treatment of patients with lichen planus should be complex and individual. At the same time, it is necessary to pay attention to comorbid diseases of the patient, which often complicate the course of skin disease. The prognosis is usually favorable. The purpose of treatment for patients with lichen planus should be based on a personalized approach to each patient, depending on the severity, form, location and clinical feature.
About the Authors
S. A. Masyukova
Moscow State University of Food Production
Russian Federation
Russian Federation
Svetlana A. Masyukova
11 Volokolamskoe highway, Moscow, 125080
S. S. Zemlyakova
Moscow State University of Food Production
Russian Federation
Russian Federation
Svetlana S. Zemlyakova
11 Volokolamskoe highway, Moscow, 125080
I. V. Ilyina
Moscow State University of Food Production
Russian Federation
Russian Federation
Inna V. Ilyina
11 Volokolamskoe highway, Moscow, 125080
V. V. Gladko
Moscow State University of Food Production
Russian Federation
Russian Federation
Viktor V. Gladko
11 Volokolamskoe highway, Moscow, 125080
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Masyukova S.A., Zemlyakova S.S., Ilyina I.V., Gladko V.V. Modern Approaches to the Treatment of Lichen Planus. Health, Food & Biotechnology. 2019;1(2):17-40. (In Russ.) https://doi.org/10.36107/hfb.2019.i2.s162
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