Preview

Health, Food & Biotechnology

Расширенный поиск

Морфин при остром коронарном синдроме и инфаркте миокарда: pro et contra

https://doi.org/10.36107/hfb.2021.i1.s92

Аннотация

В обзоре обобщены данные литературы по применению морфина у пациентов с острым коронарным синдромом и инфарктом миокарда. Кратко сообщается о возможности назначения морфина в таких клинических ситуациях в соответствии с действующими рекомендациями Организации Американской Коллегии Кардиологов/Американской Ассоциации Сердца и Европейского Общества Кардиологов. После описания фармакологических свойств морфина, подробно обсуждаются его положительные эффекты: обезболивание, улучшение гемодинамики, предполагаемое влияние на ремоделирование миокарда. Для полноценного представления о препарате приводится информация о влиянии морфина на клинические исходы – смерть, рецидив инфаркта миокарда, инсульт, кровотечение. Обзор содержит важную информацию о взаимодействии морфина с антитромбоцитарными препаратами, назначаемыми пациентам с острым коронарным синдромом и инфарктом миокарда. В заключение статьи обсуждаются необходимые варианты оптимального обезболивания пациентов с острым коронарным синдромом и инфарктом миокарда, а также востребованность в изучении новых антитромбоцитарных препаратов в этих условиях.

Об авторах

Григорий Анатольевич Игнатенко
ГОО ВПО «Донецкий национальный медицинский университет имени М. Горького»
Украина

Ректор ГОО ВПО ДОННМУ ИМЕНИ М. ГОРЬКОГО, заведующий кафедрой пропедевтики внутренних болезней, профессор, д.м.н., чл.-корр. НАМН Украины



Геннадий Геннадьевич Тарадин
ГОО ВПО "ДОННМУ ИМЕНИ М.ГОРЬКОГО" ГУ "Институт неотложной и восстановительной хирургии им. В.К. Гусака"
Украина

заведующий кафедрой терапии им. проф. А.И. Дяыка ФИПО,

отдел кардиологии и кардиохирургии, старший научный сотрудник



Ирина Валериевна Ракитская
ГОО ВПО "ДОННМУ ИМЕНИ М.ГОРЬКОГО"
Украина

доцент кафедры терапии ФИПО им. проф. А.И. Дядыка, к.м.н.



Виктория Борисовна Гнилицкая
ГОО ВПО "ДОННМУ ИМЕНИ М.ГОРЬКОГО"
Украина

доцент кафедры терапии ФИПО им. проф. А.И. Дядыка, к.м.н.



Светлана Олеговна Куликова
ГОО ВПО "ДОННМУ ИМЕНИ М.ГОРЬКОГО"
Украина


Список литературы

1. Amsterdam, E.A., Wenger, N.K., Brindis, R.G., Casey, D.E., Ganiats, T.G., Holmes, D.R., Jaffe, A.S., Jneid, H., Kelly, R.F., Kontos, M.C., Levine, G.N., Liebson, P.R., Mukherjee, D., Peterson, E.D., Sabatine, M.S., Smalling, R.W., & Zieman, S.J. (2014). 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: A report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation, 130, e344-426. http://doi.org/10.1161/CIR.0000000000000134

2. Angiolillo, D.J., Schneider, D.J., Bhatt, D.L., French, W.J., Price, M.J., Saucedo, J.F., Shaburishvili, T., Huber, K., Prats, J., Liu, T., Harrington, R.A., & Becker, R.C. (2012). Pharmacodynamic effects of cangrelor and clopidogrel: The platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials. Journal of Thrombosis and Thrombolysis, 34, 44-55. http://doi.org/10.1007/s11239-012-0737-3

3. Batchelor, R., Liu, D.H., Bloom, J., Noaman, S., & Chan, W. (2020). Association of periprocedural intravenous morphine use on clinical outcomes in ST‐elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention: Systematic review and meta‐analysis. Catheterization and Cardiovascular Interventions, 96, 76-88. http://doi.org/10.1002/ccd.28561

4. Bhatt, D.L., Stone, G.W., Mahaffey, K.W., Gibson, C.M., Steq, P.G., Hamm, C.W., Price, M.J., Leonardi, S., Gallup, D., Bramucci, E., Radke, P.W., Widimsky, P., Tousek, F., Tauth, J., Spriqqs, D., McLaurin, B.T., Anqiolillo, D.J., Genereux, P., Liu, T., Pratz, J., Todd, M., Skerjanec, S., White, H.D., & Harrinqton, R.A. (2013). Effect of platelet inhibition with cangrelor during PCI on ischemic events. New England Journal of Medicine, 368, 1303-1313. http://doi.org/10.1056/NEJMoa1300815

5. Burduk, P., Guzik, P., Piechocka, M., Bronisz, M., Rozek, A., Jazdon, M., & Jordan, M.R. (2000). Comparison of fentanyl and droperidol mixture (neuroleptanalgesia II) with morphine on clinical outcomes in unstable angina patients. Cardiovascular Drugs and Therapy, 14, 259-269. http://doi.org/10.1023/a:1007826506825

6. Caspi, O. & Aronson, D. (2020). Morphine in the setting of acute heart failure: Do the risks outweigh the benefits? Cardiac Failure Review, 28, 6:e20. http://doi.org/10.15420/cfr.2019.22

7. Chen, A., Shariati, F., Chan, T., & Lebowitz, D. (2018). A review of adverse outcomes following intravenous morphine usage for pain relief in Acute Coronary Syndrome. Cureus, 10, e3246. http://doi.org/7759/cureus.3246.

8. Corli, O., Iorno, V., Legramandi, L., Rulli, E., Roberto, A., Azzarello, G., Schiavon, S., Cavanna, L., De Santis, S., Cartoni, C., Di Marco, P., Dauri, M., Mistretta, R., Bortolussi, R., Clerico, M., Pacchioni, M., Crispino, C., Marabese, M., & Corsi, N. (2019). Oral prolonged-release oxycodone-naloxone: Analgesic response, safety profile, and factors influencing the response in advanced cancer patients. Pain Practice, Mar 27. http://doi.org/10.1111/papr.12784

9. Cowan, A., Garg, A.X., McArthur, E., Tsobo, F.M., & Weir, M.A. (2020). Cardiovascular safety of metoclopramide compared to domperidone: A population-based cohort study. Journal of the Canadian Association of Gastroenterology, XX(XX), 1–10. https://doi.org/10.1093/jcag/gwaa041

10. DeDea L. (2010). Meperidine versus morphine, and PPIs with clopidogrel. Journal of the American Academy of Physician Assistants, 23, 13. http://doi.org/10.1097/01720610-201009000-00002

11. Devereaux, A.L., Mercer, S.L., & Cunningham, C.W. (2018). DARK classics in chemical neuroscience: Morphine. ACS Chemical Neuroscience, 9, 2395-2407. http://doi.org/10.1021/acschemneuro.8b00150

12. De Waha, S., Eitel, I., Desch, S., Fuernau, G., Lurz, P., Urban, D., Schuler, G., & Thiele, H. (2015). Intravenous morphine administration and reperfusion success in ST-elevation myocardial infarction: Insights from cardiac magnetic resonance imaging. Clinical Research in Cardiology, 104, 727-734. http://doi.org/10.1007/s00392-015-0835-2

13. Ellingsrud, C. & Agewall, S. (2016). Morphine in the treatment of acute pulmonary oedema − Why? International Journal of Cardiology, 202, 870-873. http://doi.org/10.1016/j.ijcard.2015.10.014

14. Everts, B., Karlson, B., Abdon, N.J., Herlitz, J., & Hedner, T. (1999). A comparison of metoprolol and morphine in the treatment of chest pain in patients with suspected acute myocardial infarction − the MEMO study. Journal of Internal Medicine, 245, 133-141. http://doi.org/10.1046/j.1365-2796.1999.00415.x

15. Farag, M., Spinthakis, N., Srinivasan, M., Sullivan, K., Wellsted, D., & Gorog, D.A. (2018). Morphine analgesia Pre-PPCI is associated with prothrombotic state, reduced spontaneous reperfusion and greater infarct size. Thrombosis and Haemostasis, 118, 601-612. http://doi.org/10.1055/s-0038-1629896

16. Fernando, H., Nehme, Z., Peter, K., Bernard, S., Stephenson, M., Bray, J., Cameron, P., Ellims, A., Taylor, A., Kaye, D.M., Smith, K., & Stub, D. (2020). Prehospital opioid dose and myocardial injury in patients with ST elevation myocardial infarction. Open Heart, 7, e001307. http://doi.org/10.1136/openhrt-2020-001307

17. Furtado, R.H.M., Nicolau, J.C., Guo, J., Im, K., White, J.A., Sabatine, M.S., Newby, L.K., & Giugliano, R.P. (2020). Morphine and cardiovascular outcomes among patients with non-ST-segment elevation acute coronary syndromes undergoing coronary angiography. Journal of the American College of Cardiology, 75, 289-300. http://doi.org/10.1016/j.jacc.2019.11.035

18. Ghadban, R., Enezate, T., Payne, J., Allaham, H., Halawa, A., Fong, H.K., Abdullah, O., & Aggarwal K. (2019). The safety of morphine use in acute coronary syndrome: A meta-analysis. Heart Asia, 11, e011142. http://doi.org/10.1136/heartasia-2018-011142

19. Goli, R.R., Ibrahim, K., Shah, R., Kickler, T.S., Clarke, W.A., Resar, J.R., Schulman, S.P., & McEvoy, J.W. (2019). The dose and timing of fentanyl impacts on ticagrelor absorption and platelet inhibition during percutaneous coronary intervention: The PACIFY randomized clinical trial. Journal of Invasive Cardiology, 31, 265-271.

20. Gwag, H.B., Park, T.K., Song, Y.B., Kim, E,K., Jang, W.J., Yang, J.H., Hahn, J-Y., Choi, S-H., Choi, J-H., Lee, S.H., Choe, Y.H., Ahn, J., Carriere, K.C., & Gwon, H-C. (2017). Morphine does not affect myocardial salvage in ST-segment elevation myocardial infarction. PLoS One, 12, e0170115. http://doi.org/10.1371/journal.pone.0170115

21. Herndon, C.M., Jackson, K.C.2nd., & Hallin, P,A. (2021). Management of opioid-induced gastrointestinal effects in patients receiving palliative care. Pharmacotherapy, 22, 240-250. http://doi.org/10.1592/phco.22.3.240.33552

22. Hobl, E.L., Reiter, B., Schoergenhofer, C., Schwameis, M., Derhaschnig, U., Lang, I.M., Stimpfl, T., & Jilma, B. (2016). Morphine interaction with prasugrel: A double-blind, cross-over trial in healthy volunteers. Clinical Research in Cardiology, 105, 349-355. http://doi.org/10.1007/s00392-015-0927-z

23. Hobl, E.L., Stimpfl, T., Ebner, J., Schoergenhofer, C., Derhaschnig, U., Sunder-Plassmann, R., Jilma-Stohlawetz, P., Mannhalter, C., Posch, M., & Jilma, B. (2014). Morphine decreases clopidogrel concentrations and effects: A randomized, double-blind, placebo-controlled trial. Journal of the American College of Cardiology, 63, 630-635. http://doi.org/10.1016/j.jacc.2013.10.068

24. Huffman, J.C., Celano, C.M., & Januzzi, J.L. (2010). The relationship between depression, anxiety, and cardiovascular outcomes in patients with acute coronary syndromes. Neuropsychiatric Disease and Treatment, 6, 123-36. http://doi.org/10.2147/ndt.s6880

25. Iakobishvili, Z., Cohen, E., Garty, M., Behar, S., Shotan, A., Sandach, A., Gottlieb, S., Mager, A., Battler, A., & Hasdai, D. (2011). Use of intravenous morphine for acute decompensated heart failure in patients with and without acute coronary syndromes. Acute Cardiac Care, 13, 76-80. http://doi.org/10.3109/17482941.2011.575165

26. Ibanez, B., James, S., Agewall, S., Antunes, M.J., Bucciarelli-Ducci, C., Bueno, H., Caforio, A.L.P., Crea, F., Goudevenos, J.A., Halvorsen, S., Hindricks, G., Kastrati, A., Lenzen, M.J., Prescott, E., Roffi, M., Valgimigli, M., Varenhorst, C., Vranckx, P., & Widimský, P. (2017). 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal, 39, 119-177. http://doi.org/10.1093/eurheartj/ehx393

27. Iakobishvili, Z., Porter, A., Battler, A., Behar, S., Roth, A., Atar, S., Boyko, V., Mager, A., & Hasdai, D. (2010). Effect of narcotic treatment on outcomes of acute coronary syndromes. The American Journal of Cardiology, 105, 912-916. http://doi.org/10.1016/j.amjcard.2009.11.027

28. Johnson, T.W., Mumford, A.D., Scott, L.J., Mundell, S., Butler, M., Strange, J.W., Rogers, C.A., Reeves, B.C., & Baumbach, A. (2015). A study of platelet inhibition, using a 'Point of care' platelet function test, following primary percutaneous coronary intervention for ST-elevation myocardial infarction. PLoS One, 10, e0144984. http://doi.org/10.1371/journal.pone.0144984

29. Koh, J.Q.S., Fernando, H., Peter, K., & Stub, D. (2019). Opioids and ST elevation myocardial infarction: A systematic review. Heart, Lung and Circulation, 28, 697-706. http://doi.org/10.1016/j.hlc.2018.12.015

30. Kubica, J., Adamski, P., Ostrowska, M., Sikora, J., Kubica, J.M., Sroka, W.D., Stankowska, K., Buszko, K., Navarese, E.P., Jilma, B., Siller-Matula, J.M., Marszałł, M.P., Rość, D., & Koziński, M. (2016). Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: The randomized, double-blind, placebo-controlled IMPRESSION trial. Eurpean Heart Journal, 37, 245-252 http://doi.org/10.1093/eurheartj/ehv547

31. Kupnicka, P., Kojder, K., Metryka, E., Kapczuk, P., Jeżewski, D., Gutowska, I., Goschorska, M., & Chlubek, D., Baranowska-Bosiacka, I. (2020). Morphine-element interactions - The influence of selected chemical elements on neural pathways associated with addiction. Journal of Trace Elements in Medicine and Biology, 60, 126495. http://doi.org/10.1016/j.jtemb.2020.126495

32. Kurz, A. & Sessler, D.I. (2003). Opioid-induced bowel dysfunction: Pathophysiology and potential new therapies. Drugs, 63, 649-671. http://doi.org/10.2165/00003495-200363070-00003

33. McCarthy, C.P., Mullins, K.V., Sidhu, S.S., Schulman, S.P., & McEvoy, J.W. (2016). The on- and off-target effects of morphine in acute coronary syndrome: A narrative review. American Heart Journal, 176, 114-121. http://doi.org/10.1016/j.ahj.2016.04.004

34. Meine, T.J., Roe, M.T., Chen, A.Y., Patel, M.R., Washam, J.B., Ohman, E.M., Peacock, W.F., Pollack, C.V., Gibler, W.B., & Peterson, E.D. CRUSADE Investigators. (2005). Association of intravenous morphine use and outcomes in acute coronary syndromes: Results from the CRUSADE Quality Improvement Initiative. American Heart Journal, 149, 1043-1049. http://doi.org/10.1016/j.ahj.2005.02.010

35. Montalescot, G., van't Hof, A.W., Lapostolle, F., Silvain, J., Lassen, J.F., Bolognese, L., Cantor, W.J., Cequier, A., Chettibi, M., Goodman, S.G., Hammett, C.J., Huber, K., Janzon, M., Merkely, B., Storey, R.F., Zeymer, U., Stibbe, O., Ecollan, P., Heutz, W.M.J.M., Swahn, E., Collet, J.P., Willems, F.F., Baradat, C., Licour, M., Tsatsaris, A., Vicaut, E., & Hamm, C.W. (2014). Prehospital ticagrelor in ST-segment elevation myocardial infarction. New England Journal of Medicine, 371, 1016-1027. http://doi.org/10.1056/NEJMoa1407024

36. O'Gara, P.T., Kushner, F.G., Ascheim, D.D., Casey, D.E., Chung, M.K., de Lemos, J.A, Ettinger, S.M., Fang, J.C., Fesmire, F.M., Franklin, B.A., Granger, C.B., Krumholz, H.M., Linderbaum, J.A., Morrow, D.A., Newby, L.K., Ornato, J.P., Ou, N., Radford, M.J., Tamis-Holland, J.E., Tommaso, C.L., Tracy, C.M., Woo, Y.J., Zhao, D.X., Anderson, J.L., Jacobs, A.K., Halperin, J.L., Albert, N.M., Brindis, R.G., Creager, M.A., DeMets, D., Guyton, R.A., Hochman, J.S., Kovacs, R.J., Kushner, F.G., Ohman, E.M., Stevenson, W.G., & Yancy, C.W. (2013). American College of Cardiology Foundation/American Heart tеask force on practice guidelines. ACCF/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 127, e362-425. http://doi.org/10.1161/CIR.0b013e3182742cf6

37. Parodi, G., Bellandi, B., Xanthopoulou, I., Capranzano, P., Capodanno, D., Valenti, R., Stavrou, K., Migliorini, A., Antoniucci, D., Tamburino, C., & Alexopoulos, D. (2014). Morphine is associated with a delayed activity of oral antiplatelet agents in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Circulation: Cardiovascular Intervention, 8, e001593. http://doi.org/10.1161/CIRCINTERVENTIONS.114.001593

38. Parodi, G., Xanthopoulou, I., Bellandi, B., Gkizas, V., Valenti, R., Karanikas, S., Migliorini, A., Angelidis, C., Abbate, R., Patsilinakos, S., Baldereschi, G.J., Marcucci, R., Gensini, G.F., Antoniucci, D., & Alexopoulos D. (2015). Ticagrelor crushed tablets administration in STEMI patients: The MOJITO study. Journal of the American College of Cardiology, 65, 511-512. http://doi.org/10.1016/j.jacc.2014.08.056

39. Parodi G. (2016). Editor's Choice-Chest pain relief in patients with acute myocardial infarction. Eur Heart J Acute Cardiovasc Care, 5, 277-281. http://doi.org/10.1177/2048872615584078

40. Pasternak, G.W. (2010). Molecular insights into mu opioid pharmacology: From the clinic to the bench. The Clinical Journal of Pain, 26 Suppl 10(Suppl 10), S3-9. http://doi.org/10.1097/AJP.0b013e3181c49d2e

41. Pasternak, G.W. (2012). Preclinical pharmacology and opioid combinations. Pain Medicine, 13 Suppl 1(s1), S4-11. http://doi.org/10.1111/j.1526-4637.2012.01335.x

42. Pergolizzi, Jr.J.V., Christo, P.J., LeQuang, J.A., & Magnusson, P. (2020). The use of peripheral μ-opioid receptor antagonists (PAMORA) in the management of opioid-induced constipation: An update on their efficacy and safety. Drug Design, Development and Therapy, 14, 1009-1025. http://doi.org/10.2147/DDDT.S221278

43. Puymirat, E., Lamhaut, L., Bonnet, N., Aissaoui, N., Henry, P., Cayla, G., Cattan, S., Steg, G., Mock, L., Ducrocq, G., Goldstein, P., Schiele, F., Bonnefoy-Cudraz, E., Simon, T., & Danchin, N. (2016). Correlates of pre-hospital morphine use in ST-elevation myocardial infarction patients and its association with in-hospital outcomes and long-term mortality: The FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) programme. Eurpean Heart Journal, 37, 1063-1071. http://doi.org/10.1093/eurheartj/ehv567

44. Rajani, S.F., Imani, A., Faghihi, M., Izad, M., Kardar, G.A., & Salehi, Z. (2019). Post-infarct morphine treatment mitigates left ventricular remodeling and dysfunction in a rat model of ischemia-reperfusion. European Journal of Pharmacology, 847, 61-71. http://doi.org/10.1016/j.ejphar.2019.01.023

45. Roffi, M., Patrono, C., Collet, J.P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J.J., Borger, M.A., Brotons, C., Chew, D.P., Gencer, B., Hasenfuss, G., Kjeldsen, K., Lancellotti, P., Landmesser, U., Mehilli, J., Mukherjee, D., Storey, R.F., & Windecker, S. (2016). ESC scientific document group. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eurpean Heart Journal, 37, 267-315. http://doi.org/10.1093/eurheartj/ehv320

46. Sandoval, Y. & Jaffe, A.S. (2019). Type 2 Myocardial infarction: JACC review topic of the week. Journal of the American College of Cardiology, 73, 1846-1860. http://doi.org/10.1016/j.jacc.2019.02.018

47. Sheu, J.R., Yeh, G.C., Fang, C.L., Lin, C.H., & Hsiao, G. (2002). Morphine-potentiated agonist-induced platelet aggregation through alpha2-adrenoceptors in human platelets. Journal of Cardiovascular Pharmacology, 40, 743-750. http://doi.org/10.1097/00005344-200211000-00012

48. Steg, Ph.G., James, S.K., Atar, D., Badano, L.P., Blömstrom-Lundqvist, C., Borger, M.A., Mario, C.Di., Dickstein, K., Ducrocq, G., Fernandez-Aviles, F., Gershlick, A.H., Giannuzzi, P., Halvorsen, S., Huber, K., Juni, P., Kastrati, A., Knuuti, J., Lenzen, M.J., Mahaffey, K.W., Valgimigli, M., van't Hof, A., Widimsky, P., & Zahger, D. (2012). ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eurpean Heart Journal, 33, 2569-2619. http://doi.org/10.1093/eurheartj/ehs215

49. Xanthopoulou, I., Davlouros, P., Tsigkas, G., Koutsogiannis, N., Patsilinakos, S., Deftereos, S., Hahalis, G., & Alexopoulos, D. (2016). Factors affecting platelet reactivity 2 hours after P2Y₁₂ receptor antagonist loading in primary percutaneous coronary intervention for ST-elevation myocardial infarction - impact of pain-to-loading time. Circulation Journal, 80, 442-449. http://doi.org/10.1253/circj.CJ-15-0495

50. Yuan, C.S., Foss, J.F., O'Connor, M., Osinski, J., Karrison, T., Moss, J., & Roizen, M.F. (2000). Methylnaltrexone for reversal of constipation due to chronic methadone use. JAMA. 283, 367-372. http://doi.org/10.1001/jama.283.3.367

51. Wu, L.N., Hu, R., & Yu, J.M. (2021). Morphine and myocardial ischaemia-reperfusion. Europian Journal of Pharmacology, 891, 173683. http://doi.org/10.1016/j.ejphar.2020.173683


Рецензия

Для цитирования:


Игнатенко Г.А., Тарадин Г.Г., Ракитская И.В., Гнилицкая В.Б., Куликова С.О. Морфин при остром коронарном синдроме и инфаркте миокарда: pro et contra. Health, Food & Biotechnology. 2021;3(1):13-29. https://doi.org/10.36107/hfb.2021.i1.s92

For citation:


Ignatenko G.A., Taradin G.G., Rakitskaya I.V., Gnilitskaya V.B., Kulikova S.O. Morphine in acute coronary syndrome and myocardial infarction: pro et contra. Health, Food & Biotechnology. 2021;3(1):13-29. (In Russ.) https://doi.org/10.36107/hfb.2021.i1.s92

Просмотров: 1601


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2712-7648 (Online)