Chemical composition and actoprotective activity of extracts from the grass Lysimachia punctata L. (Verbena Pointness)
https://doi.org/10.36107/hfb.2021.i4.s108
Abstract
An important task of modern pharmacology and medical chemistry is to expand the range of effective and safe medicines. In this regard, the scientific community is paying more and more attention to objects of plant origin. The aim of the study was to study the chemical composition of the extraction of verbena pointness grass and to evaluate its actoprotective activity. The total content of flavonoids was determined by the spectrophotometric method. The amino acid and trace element composition in the extraction of verbena pointness grass was determined by capillary electrophoresis. The actoroprotective activity of the extraction of verbena pointness grass was evaluated on male mice of the Balb/c line in the forced swimming with load test. The effect of the studied extraction on the change in the activity of succinate dehydrogenase and cytochrome-c oxidase in muscle tissue was also determined. During the study, it was found that 12 free amino acids were found in the analyzed extract, of which 6 are essential (arginine, β-phenylalanine, leucine, methionine, threonine, valine), with a flavonoid content from 0.57% to 0.60%. The analyzed extraction is quantitatively dominated by potassium among trace elements. The use of the studied extract increased the level of efficiency of animals by 156.6% (p<0.05) with an increase in the activity of cytochrome-c-oxidase and succinate dehydrogenase by 40.5% (p<0.05) and 61.5% (p<0.05), respectively. Thus, it was found that the extraction of verbena pointness grass is characterized by a rich chemical composition and the presence of actoprotective potential, which makes it a promising object for further study.
About the Authors
Similla L. Adjiakhmetova
Pyatigorsk Medical and Pharmaceutical Institute-branch of the Volgograde State Medical University
Russian Federation
Russian Federation
Nadezhda M. Chervonnaya
Pyatigorsk Medical and Pharmaceutical Institute-branch of the Volgograde State Medical University
Russian Federation
Russian Federation
Dmitry I. Pozdnyakov
Pyatigorsk Medical and Pharmaceutical Institute-branch of the Volgograde State Medical University
Russian Federation
Russian Federation
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For citations:
Adjiakhmetova S.L., Chervonnaya N.M., Pozdnyakov D.I. Chemical composition and actoprotective activity of extracts from the grass Lysimachia punctata L. (Verbena Pointness). Health, Food & Biotechnology. 2021;3(4). (In Russ.) https://doi.org/10.36107/hfb.2021.i4.s108
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