Prospects for the development of solid dispersed systems of antibiotics (scoping review)

Abstract

Introduction. Currently, there is a large number of antibacterial medications for the treatment of infectious diseases on the pharmaceutical market. Fluoroquinolones, being an important group among these medications, have a wide spectrum of action and are active against multiresistant bacteria, one of which is ofloxacin. Ofloxacin is characterized by low solubility and belongs to the second class according to the biopharmaceutical classification of medications, so it is advisable to use the method of introducing it into solid carriers to increase bioavailability. 

Purpose of the article is to describe methods for obtaining new dosage forms of ofloxacin with increased bioavailability. 

Materials and methods: Having analyzed the literature on the topic, the authors presented a brief description of the methods and techniques for the manufacture of solid dispersions with this active substance. 

Results and conclusion: The effect of other excipients, such as surfactants, on the release of the medication from the formulation has been described. The physicochemical and biopharmaceutical methods that can be used to establish the quality of the newly developed dosage form of ofloxacin are reflected. Using the methods described in the article, it is possible to create a new dosage form of ofloxacin with improved biopharmaceutical performance in relation to existing medications on the market. This method will allow the creation of a prolonged drug with fewer side effects and more profitable in economic terms.