Realization of the Therapeutic and Preventive Potential of Health–Improving Food Products — Focus on Effectiveness (Review of Research Methodology)
https://doi.org/10.36107/hfb.2024.i1.s199
Abstract
Introduction. Currently, the Russian market of products with special health effects (POVZ) is not developing dynamically enough; the real benefits of such products often do not meet consumer expectations. It is assumed that one of the reasons for this is the lack of reliably confirmed effectiveness, dosage, duration of exposure to the body and aftereffects.
Purpose. The authors set a goal to present a modern methodology for solving these problems at various levels, including cellular and organismal, based on an analysis of domestic and foreign publications in recent years.
Materials and Methods. To write this review, peer-reviewed original articles, reviews and monographs published in Russian and English between 2003 and 2023 were used. The studied selection of sources included 112 publications posted in domestic and foreign databases, such as Scopus, Web of Science, SciHub, PubMed, Google scholar, e-library and RISC. When analyzing publications for relevance to the topic, 56 sources were selected, which were further examined in detail.
Results. The authors presented the state of legal regulation of the effectiveness of POVZ in Russia and abroad, and also discussed the following issues: biological models in vitro and in vivo for testing the effectiveness of POVZ, an integrated approach to studying the immunotropic activity of POVZ, foodomics and artificial intelligence for analysis efficiency of POVZ.
Conclusions. Experiments on in vitro biomodels will remain in the future importance for assessing the molecular and cellular mechanisms of action of POVZ, as well as the magnitude of the effect, while in vivo experiments will not only provide a systematic analysis of the results obtained, but will also specify the dose, the required duration of exposure and the duration of the aftereffect, as well as other characteristics of the health product being studied.
About the Authors
Aleksandra S. Utkina
Plekhanov Russian University of Economics
Russian Federation
Russian Federation
Polina G. Molodkina
Plekhanov Russian University of Economics
Russian Federation
Russian Federation
Vasily P. Karagodin
Plekhanov Russian University of Economics
Russian Federation
Russian Federation
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Utkina A.S., Molodkina P.G., Karagodin V.P. Realization of the Therapeutic and Preventive Potential of Health–Improving Food Products — Focus on Effectiveness (Review of Research Methodology). Health, Food & Biotechnology. 2024;6(1). (In Russ.) https://doi.org/10.36107/hfb.2024.i1.s199
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