The article addresses the issue of outdated contact email addresses in scientific publications, which obstructs effective scientific communication and the reproducibility of research findings. Possible solutions are discussed, including the mandatory use of institutional email addresses, their forwarding, and integration with online identifiers such as ORCID. The authors emphasize the need for strict journal policies to improve the transparency and sustainability of contact data. Particular attention is paid to solutions that can improve the interaction between authors and readers of research articles.

Introduction. According to statistics, in 2022, 3,324.4 thousand newly diagnosed diseases with certain infectious and parasitic diseases were registered in the Russian Federation. Of these, 22.7 cases were detected for the first time per 1000 people of the population. The situation is further complicated by the emergence of new multidrug-resistant and broadly resistant strains, as well as fatal synergism with HIV./AIDS infection. 

Purpose. The development of new compounds with an adequate safety profile and with fungicidal and antiparasitic effects is necessary for effective treatment and complete cure of the disease. Assessment of the acute and chronic toxicity of a new drug is a necessary step in preclinical safety research. In this regard, the purpose of this work was to determine the acute and chronic toxicity of the developed chemical compound. 

Materials and Methods. The chemical substance pyrimidine 2,4 dione (1 amino, 6-methyl pyrimidine 2,4 dione) (PD-2,4) was synthesized on the basis of the Ural State University and was a white crystalline powder. During the study, the test sample was stored in the dark at a temperature of 5-6 ° C and dissolved in 0.7% sodium bicarbonate solution. The assessment of acute and chronic toxicity was carried out according to the guidelines for conducting preclinical studies of medicines. The experiments were reviewed in advance and approved by the UGMU Animal Ethics Committee. 

Results. When studying the acute toxicity of the drug (PD-2,4) in outbred white mice and rats of both sexes with oral or intraperitoneal administration, it was not possible to determine the average lethal dose due to the lack of death of animals in conditions of achieving the maximum possible concentrations and the maximum allowable volumes of administration. 

Conclusions. As a result of the study, it was found that PD-2,4 is low-toxic with oral and intraperitoneal administration and, according to the classification of K.K. Sidorov (1973), can be classified as a 4th class of toxicity.

Introduction. The use of protein-rich legumes together with grain raw materials and spices with increased biological value allows enriching products with bioavailable phenolic antioxidants and balancing the amino acid composition. The resulting dry functional mixtures will affect the basic physiological processes of the body and strengthen the immune system. 

Purpose. To identify the relationship between dry functional mixtures, their properties and the physical and chemical indicators of grain legumes; to analyze raw materials, dry functional mixtures, grinding batches, properties.

Materials and Methods. Physical properties: the linear dimensions of the grains were determined using a micrometer with an accuracy of 0.01 mm; the grain nature was determined according to GOST 10840-64; grain vitreousness according to GOST 10987-76; grain and processed product moisture content according to GOST 13586.5-93 and GOST 8.434-81.

Results. The functional and technological properties of dry functional mixtures (DFM) were determined: granulometric composition, degree of grinding; physicochemical indicators of grain legume raw materials: geometric parameters, grain shape, uniformity in size, saturation of the finished product with biologically active substances. Developed by SPS %: 3ВС-2 and 4ДС-3 (buckwheat - 37, peas - 15, millet - 24, pearl barley - 9, spelt - 5, rye - 9, allspice - 0.2). The degree of grinding of SFS is 132 μm. The yield of intermediate products of grinding of the presented two grinding batches of grain legume raw materials on five grain-forming torn and seven grinding systems is fractions of 157-250 μm.

Conclusions. The obtained results can be used in the production of flour culinary products in public catering establishments, as well as in mini-bakeries. The technological properties of grain legume raw materials are the criteria for choosing milling schemes and obtaining the optimal yield of powdered dry functional mixtures.

Introduction. In the production of fruit materials, fruits and berries are used, which can be contaminated with pesticides, which negatively affect not only the quality and safety of finished products, but also the technological process of obtaining. Thus, ensuring the safety of fruit materials and fruit wines from them is an important task of the manufacturer. 

Purpose. To study the effect of organophosphate pesticides during the fermentation process of fruit material on the morphology and physiological activity of the yeast cell.

Materials and Methods. The objects of the study were selected pesticides dimethoate, pyrimiphos-methyl, malathion, which are pure solutions, as well as yeast Saccharomyces cerevisiae of the Malic 7 race, grown in the laboratory. Apple material obtained from fresh apples was chosen as the research medium.

Results. The results of the study show that in the presence of pesticides in the environment, the yeast cell is able to respond by changing the morphology of the yeast

Conclusions. The obtained data can be used in the production of fruit materials and wines.

Introduction. One of the important factors in the need to develop biodegradable packaging is the presence of its non-decomposable variations in waste up to 50%. In this regard, the modification of biodegradable polymers to impart high performance properties while maintaining the ability to biodegrade is an urgent task.

Purpose. To consider the current state and the use of biodegradable materials in Russia and abroad.

Materials and Methods. The selection of studies was carried out in two stages: a  decision was made to include a publication in the review based on its title and abstract, and full-text articles were studied for a detailed assessment of compliance with the inclusion criteria. An assessment of the research quality was conducted. During data synthesis, the results of individual studies were compared, combined, and summarized. The review included articles published from 1999 to 2024. The articles were selected based on the number of citations for the following keywords: biodegradable packaging, medicine, pharmaceuticals, environment, food technology, biomass and chemical synthesis. 

Results. As a result of this interactive search, 56 studies were identified. After analyzing the research, it was found that the variety of biodegradable polymers allows them to unlock their potential for use in various fields. A wide range of such polymers provides an opportunity to create new materials that can efficiently decompose in nature and have the performance properties we need. Also, most studies have not found adverse effects for various organisms, and only a limited statement can be made about the environmental compatibility of biodegradable polymers. The use of various modifications has led to the expansion of the utilization of edible and biodegradable films, which is associated with an improvement in the general characteristics of biopolymers, increasing their mechanical, thermal and barrier properties, usually even at very low content. Thus, modifiers play an important role in increasing the efficiency of biopolymers application, which reduce the amount of packaging waste associated with processed foods and contribute to the preservation of products by extending their shelf life.

Conclusions. This article discusses biodegradable polymers and compositions based on them, the current state and use of biodegradable materials in various fields. Modern studies on the assessment of the possible impact of biodegradable polymers on the environment are presented. Promising trends in the use of biodegradable polymers in the food industry, as well as in medicine and pharmaceuticals are shown.