Approaches to creating an efficient Discussion section in research articles are analyzed. The necessity of perceiving the section as a platform for informing the reader about the authors’ contribution to the existing knowledge on the topic is emphasized. The content functionality of each section of the manuscript is a strategically significant step that increases the visibility of the published article. The author's ability to substantiate the significance of the results obtained in comparison with the data of previously published studies, understanding and commenting on the limitations of his own research indicate the levels of the author's expertise in the topic. The examples reveal the main accents of the successful Discussion section. A checklist for tracking the structural integrity of the section is presented, ideas for optimizing the content of the section are proposed.

The modern pharmaceutical market is represented by a large number of natural and synthetic (recombinant) interferon drugs, available in different dosage forms for both local and systemic action, but the data on the safety of this group of drugs is rather limited. This requires additional study of the features and severity of adverse reactions (AR) associated with the use of this pharmaceutical group in the treatment of various nosologies. The aim of the study was to study the main manifestations and the incidence of AR when using drugs of the interferon group in patients living in the Republic of Crimea. The objects of the study were the cards-notifications about AR registered in the regional database (Republic of Crimea) of data of AR ARCADE (Adverse Reactions in Crimea, Autonomic Database) for the period 01.01.2010-31.12.2018. The analysis of spontaneous messages was carried out according to the following indicators: correspondence of the dose of the drug that caused the AR, the patient’s age, indications for the use of the suspected drug, the distribution of the presented AR cases by the route of drug administration, clinical manifestations of AR, patients’ allergological history, drug correction and measures, directed to stop AR and the number of simultaneously prescribed drugs. During the analyzed period, in the ARCADe database 57 cases of AR of the interferons were registered. Interferon alfa-2b drugs were the leaders in the frequency of AR development. The total number of registered AR cases for them was 42 cases (73.7% of the total number of cases). The most frequent clinical manifestations of AR were allergic reactions of the immediate type (48 cases, 84.2%), among which local allergic reactions in the form of urticaria, hyperemia, papular rash predominated (45 cases, 79%). Immediate life-threatening allergic reactions after administration of interferon alfa- 2b were observed in 3 cases: 2 cases (3,5%) of angioedema (Quincke’s edema) and 1 case of anaphylactic shock. The results obtained indicate a sufficient risk of developing life- threatening conditions against the background of the use of drugs of the interferon group, which requires healthcare professionals to carefully study the patient’s allergic history, as well as control his well-being at the entire stage of treatment.

The presence of microscopic particles of plastic (MP) in food is currently an urgent problem in the modern food industry and one of the main issues of food safety. However, there are no clear methods for the determination of such particles, nor methods for cleaning food products from them. In the present work, for the first time, the method of Dynamic Laser Light Scattering (DLS) was used to determine the plastic nanoparticles from tea bags when they were boiled in boiling water. It has been established that some of the studied samples of sachets release a huge amount of such nanoparticles into water. Moreover, hundreds of millions of nanoparticles are released per one microscopic particle. Pyramidal tea bags release a huge amount of nanoparticles with a diameter of 1 to 2 nm. The number of nanoparticles released during thermal action on pyramidal tea bags is at least 23 times greater than the number of the

A technology has been developed for obtaining an osteoplastic material consisting of a powder of natural bone tissue, the preparation contains hydroxyapatite and tricalcium phosphate compounds, as well as a complex of minerals. One of the most urgent problems of traumatology and orthopedics, surgical dentistry and maxillofacial surgery is the problem of treating patients with large bone defects. A distinctive feature of such defects is the insufficient severity of the natural regenerative processes of bone tissue. Thus, the development of a technology for obtaining bone blocks for further use as a fully bioinert and biocompatible osteoinductive material on the world market that is fully bioinert and biocompatible with body tissues for plastic compensation of bone defects of the jaw bones is relevant. The resulting material was a complex structured system consisting of specially treated bone tissue obtained from slaughter animals (bulls up to 12-18 months of age), containing bioavailable silicon and a number of biologically active compounds that stimulate reparative processes in bone tissue. An optimal technological scheme for obtaining an osteinductive material has been developed. The composition and main stages of the developed technology have been optimized. Bone material accumulated using the developed technology was used in further research on the development of complex dosage forms that have an osteoinductive effect.

Fruit, berry and vegetable raw materials are an irreplaceable item in human nutrition. At this stage in the development of world breeding, not only the organoleptic characteristics of plants, but also their chemical composition, come to the fore. In connection with the growing interest in the effect of antioxidants on human health, breeders are increasingly turning their attention to the study of their comparative content in fruit, berry and vegetable raw materials. The results of a study of the influence of the grade of plant raw materials on the accumulation of substances exhibiting antioxidant activity (phenols, flavonoids, carotenoids) are presented. Popular vegetables and fruits cultivated and growing wild in the Samara region were selected as objects of research. The aim of the study is to obtain new information on the influence of such factors as the type and variety of fruit, berry and vegetable raw materials on substances with antioxidant activity (phenols, flavonoids, carotenoids). In the extracts of the analyzed samples, the total content of phenolic substances was determined by the method using the Folin-Ciocalteu reagent, flavonoids by the method based on the formation of a flavonoid-aluminum complex. The carotene content was determined according to GOST 8756.22-80 using acetone and hexane as extractants. The results of the study showed that the type and variety of plant raw materials are factors that directly affect the accumulation of the studied substances. To a greater extent, the results obtained relate to varieties of sweet peppers, fresh food pumpkin, rose hips. Significant variation in carotene content was recorded in pumpkin samples: from 1.20 to 4.90 mg%. Among the objects of research, it is recommended to use the fruits of the wild rose as a source of phenolic substances and carotenoids for the food and pharmaceutical industries. The work was carried out within the framework of the state assignment for fundamental research of the Federal State Budgetary Educational Institution of Higher Education «Samara State Technical University» No. 0778-2020-0005.

The article discusses the effectiveness of adding various processing aids to determine the effectiveness of replacing a batch of wheat flour with buckwheat and its influence on such parameters as water absorption capacity of flour, formation time and dough stability during kneading. Buckwheat is a traditional agricultural crop, its processed products have a significant potential in the field of food bioconversion of raw materials. The increased interest in this crop is due to its chemical composition and a complex of useful qualities that have benifits on the human body, due to the presence of a high content of vitamins P, PP, B1, B2 and E. All this makes it possible to increase the nutritional and biological values of bakery and flour confectionery products. The specificity of the use of non-traditional types of raw materials and ingredients in this area, the peculiarities of production and the lack of balance in formulations encourage scientific and technological research. The creation of a complex food additive based on buckwheat flour as a carrier, together with enzyme preparations, makes it possible to produce functional mixtures for the production of bakery and flour confectionery products of stable quality. Also, the actual development is the process of bioconversion of buckwheat flour and the creation of dry buckwheat sourdough, which will facilitate the mass production of bakery products with a dietary preventive focus