Introduction. Keywords, reflecting the main content of the article, play an extremely important role in the search for scientific papers in databases. Together with title and abstract, keywords provide primary information about the study. Selecting and extracting effective keywords is a time-consuming process, so its optimization requires further studying.

Purpose. The article is aimed at acquainting the authors of the journal with methods for keywords extracting and optimizing.

Results. The phenomenon of "keyword optimization", keyword extracting strategies aimed at increasing the visibility of an article are analyzed. The advantages of optimizing the extracting of keywords are commented. The stages of the keyword optimization process are considered. The stages of keyword optimization are analyzed. The possibilities of using platforms and tools for extracting keywords are described. The factors influencing the criteria for selecting and extracting keywords are explained. Approaches to identifying typical mistakes in the selection of keywords are commented.

Implementation of the results obtained. The examples of keyword extraction tools presented in this editorial will help authors optimize the keywords of their research articles and increase their visibility in scientometric databases and the citation of their work. The described keyword selection strategies are designed to help authors improve metadata and search engine optimization.

Relevance of the study and the presence of gaps in existing knowledge on topic. The use of inhalation bronchodilators and glucocorticosteroids (GCS) improves the functional parameters of the lungs in patients with chronic obstructive pulmonary disease (COPD), as well as reduces the number of middle and severe exacerbations. There are a large number of inhalation drugs in the modern Russian pharmaceutical market, which are both monocomponent and combinations of two and three drugs. Often, original and generic drugs have different costs and are not always economically or physically available to different population segments.

Thus, the aim of this study was to conduct a comparative pharmacoeconomic analysis of inhalation bronchodilators and anti-inflammatory drugs to determine the level of economic availability. 

Materials and Methods. Drugs from the group of adrenomimetics for inhalational use (ATC code R03A), anticholinolytic and GCS for inhalation used in the COPD treatment (ATC code R03B) were analyzed. Information about the price of drugs is obtained from the state register of maximum selling prices and the Internet resource "Apteka.ru". To evaluate the availability of the analyzed groups of drugs, solvency adequacy coefficients (Ca.s) and price liquidity indicators (Cliq) were calculated.

Results. The most available among the GCS was beclomethasone in form of a metered-dose inhalator (MDI) 50 mcg (Cliq = 52%; Ca.s = 0.338%), among short-acting emergency bronchodilators, salbutamol in MDI form 100 mcg (Cliq= 58%; Ca.s = 0.156%) was the most available. Greater availability was found for domestic drug manufacturers (95% CI: 0.690 - 1,000; p = 0.007), however, the opposite data were obtained for several drugs.

Conclusions. The obtained results show a heterogeneous structure among the levels of inhalation drugs availability used in COPD treatment. Taking into account the wide range of drug products, in order to inform medical and pharmaceutical workers in a timely way, it is advisable to systematically study these drug groups using pharmacoeconomic analysis methods.

Medical science recognizes that patients do not always respond to treatment in a way physicians expect; moreover, different people respond to treatment in different and sometimes unpredictable ways. These differences can be attributed to observable patients’ characteristics, such as age and gender, but also unobservable characteristics can influence the results, such as lifestyle or an unreported health condition. To overcome this problem, during the twentieth century, medical researchers and statisticians began extensively using randomized controlled trial (RCT) methods to assess the effect of the treatment and to separate this effect from other patients’ characteristics that could affect the results. During the last decades, social scientists, willing to go beyond correlational analysis to provide insights on causation, have adopted a similar approach. This paper gives a short overview of RCT in development economics with a special attention to programs related to health in developing countries.

An important task of modern pharmacology and medical chemistry is to expand the range of effective and safe medicines. In this regard, the scientific community is paying more and more attention to objects of plant origin. The aim of the study was to study the chemical composition of the extraction of verbena pointness grass and to evaluate its actoprotective activity. The total content of flavonoids was determined by the spectrophotometric method. The amino acid and trace element composition in the extraction of verbena pointness grass was determined by capillary electrophoresis. The actoroprotective activity of the extraction of verbena pointness grass was evaluated on male mice of the Balb/c line in the forced swimming with load test. The effect of the studied extraction on the change in the activity of succinate dehydrogenase and cytochrome-c oxidase in muscle tissue was also determined. During the study, it was found that 12 free amino acids were found in the analyzed extract, of which 6 are essential (arginine, β-phenylalanine, leucine, methionine, threonine, valine), with a flavonoid content from 0.57% to 0.60%. The analyzed extraction is quantitatively dominated by potassium among trace elements. The use of the studied extract increased the level of efficiency of animals by 156.6% (p<0.05) with an increase in the activity of cytochrome-c-oxidase and succinate dehydrogenase by 40.5% (p<0.05) and 61.5% (p<0.05), respectively. Thus, it was found that the extraction of verbena pointness grass is characterized by a rich chemical composition and the presence of actoprotective potential, which makes it a promising object for further study.

Advances in the development of modern snack bar formulations demonstrate the wide variety of ingredients used and their combinations. At the same time, the prevailing trends in the food market orient manufacturers towards the active use of ingredients of plant origin. Analysis of literary sources made it possible to substantiate the choice of recipe ingredients for creating a functional snack bar: processed products of raspberries and blueberries, apples, dates, cashews, soy protein isolate. The use of a new combination of known ingredients requires solving a number of problems that make a key contribution to the creation of product technology and the development of its formulation. The aim of the study was to experimentally substantiate and develop a recipe for a ready-to-eat functional snack bar based on herbal ingredients. The work used raw materials that meet the requirements of GOST, TU, and generally accepted methods of analysis: determination of polyphenolic compounds, flavones, flavonols was carried out by spectrophotometric method; organic acids and vitamin C - by titrimetric method; nutritional value of snack bar samples by protein, fat, carbohydrates and dietary fiber content - by calculation method. As a result of the research carried out, the recipe for the snack bar was experimentally substantiated and developed, taking into account the new composition of the selected herbal ingredients; technological solutions for its implementation are proposed. It has been shown that berry ingredients used in work (concentrated raspberry and blueberry juices, freeze-dried blueberry powder and freeze-dried raspberries) are a source of natural components useful for human health - organic acids, polyphenolic compounds, including flavones and flavonols, as well as vitamin C. The combination of berry ingredients with other recipe components - date paste, apple syrup, apple fibers, soy protein isolate, cashew nuts - results in a finished product with acceptable taste and consumer properties and an increased content of protein and functional food ingredients - vitamin C and dietary fiber. It was found that the consumption of one serving (50 g) of a snack bar obtained according to the proposed recipe allows satisfying the physiological need of an adult in protein by 5.7-10.8%, fats - 1.1-2.5%, digestible carbohydrates - 5.4 -12.6%, dietary fiber - 14.4 -18.0%, vitamin C - 11.2%, covering an adequate level of consumption of flavones and flavonols - by 45.5%. The snack bar obtained according to the developed recipe contains only natural sugars and can be positioned as a product that is a source of protein, vitamin C and a product with a high dietary fiber content. The results of the research carried out can be recommended for use in production to expand the assortment line of healthy snacks. For the development of a complete package of technological solutions, directions for further research are outlined, which will be aimed at finding and justifying effective packaging solutions that ensure the quality, safety of the product and the safety of biologically active substances during storage

Food sonochemistry is a relatively new scientific field; it studies the processes occurring during the transformation of the energy of elastic vibrations of ultrasonic frequency in liquid food media. In our country, studies of sonochemical technologies in the branches of the agro-industrial complex and related equipment (cavitation reactors) for their implementation began in the early 2000s. A significant contribution to the development of sonochemistry in the food industry was made by prof. Shestakov SD, prof. Polandova R.D., prof. Panfilov V.A., prof. Krasulya O.N., prof. Potoroko I.Yu. and others. The concept of food sonochemistry was formed, domestic low-frequency cavitation equipment for processing liquid food media was created, and a study was made of the possibility of its use in the meat, bakery and dairy industries. The obtained research results convincingly testify to the effectiveness of the developed cavitation technologies in the above-mentioned branches of the agro-industrial complex. The prospects for the use of these energy-saving technologies are beyond doubt, which is consistent with the results of research by leading foreign scholars, as well as with the Strategy for the Development of the Agro-Industrial Complex for the period up to 2030, which emphasizes the need for a wider use of cavitation technologies on an industrial scale.

Currently, the range of new types of food products is constantly growing, the preservation of which requires the use of modern packaging materials and technologies that allow extending the shelf life of food. For this purpose, multilayer materials are widely used for packaging. This is due to the unlimited possibilities of varying their properties to provide a set of functional requirements. A few years ago, a new technology for packaging products in vacuum using multilayer materials, called "SKIN", appeared on the world market of packaging equipment under the influence of technological improvement and marketing factors. The Italian company ILPRA SPA, having its own production facilities, extensive experience in the design and manufacture of packaging equipment, was one of the first companies to introduce this technology.

The "SKIN" technology is one of the best in achieving the shelf life of products without subjecting it to heat treatment after packaging.